Infertility Continual use of opioids, which include codeine, a component of promethazine HCl and codeine phosphate oral Remedy, could induce decreased fertility in girls and males of reproductive probable.
The opioid antagonists, naloxone and nalmefene, are particular antidotes for respiratory despair ensuing from opioid overdose. For clinically major respiratory or circulatory melancholy secondary to codeine overdose, administer an opioid antagonist. An antagonist should not be administered during the absence of clinically major respiratory depression. As the length of opioid reversal is expected to become a lot less than the period of motion of codeine in promethazine HCl and codeine phosphate oral Alternative, thoroughly keep an eye on the patient until eventually spontaneous respiration is reliably reestablished.
Breathing issues (respiratory melancholy) that may result in Demise and opioid withdrawal can come about if You begin having or halt using other medicines when taking Promethazine Hydrochloride and Codeine Phosphate Oral Resolution, which include:
The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are sophisticated, necessitating careful thought of the results to the father or mother drug, codeine, plus the Lively metabolite, morphine.
Overdose of codeine in Grownups has been related to lethal respiratory melancholy, and using codeine in children younger than twelve many years of age has been related to lethal respiratory depression when applied as suggested [see Warnings and Safeguards (5.
Shop merchandise from compact company makes bought in Amazon’s retail store. Uncover more about the small companies partnering with Amazon and Amazon’s commitment to empowering them. Find out more
INDICATIONS AND Utilization Promethazine HCl and codeine phosphate oral Alternative is a combination of codeine, an opioid agonist, and promethazine, a phenothiazine, indicated for your short term relief of cough and upper respiratory symptoms associated with allergy or even the widespread chilly in people eighteen a long time of age and older. (1) (1)
Good assessment in the patient, good prescribing methods, periodic re-analysis of therapy, and suitable dispensing and storage are ideal measures that help to limit abuse of opioid medications.
Unresponsive Cough The dosage of promethazine HCl and codeine phosphate oral Option really should not be amplified if cough fails to respond; an unresponsive cough must be reevaluated in five days or faster for doable fundamental pathology, for instance overseas overall body or decrease respiratory tract condition [see Dosage and Administration (2.three)].
With zero destructive Uncomfortable side effects, Legal Lean is a clean solution to improve your temper & enhance your slumber.
Marketing or giving away Promethazine with Codeine Oral Option may damage Many others, which is against the legislation. Notify your Health care supplier When you have at any time abused or been dependent on Liquor, prescription medicines or Road medication. Promethazine with Codeine Oral Option is not for children below 6 several years of age.
Human Details Posted knowledge from situation-Handle and observational reports on codeine use for the duration of pregnancy are inconsistent within their conclusions. Some scientific tests of codeine exposure confirmed a heightened danger of overall congenital malformations while some didn't. An increased threat of precise malformations with codeine exposure for example respiratory malformations, spina bifida and congenital coronary heart defects ended up documented in click here a few studies.
Stay clear of using promethazine HCl and codeine phosphate oral solution in adolescents twelve to eighteen decades of age who produce other hazard factors which could enhance their sensitivity to your respiratory depressant outcomes of codeine Until the benefits outweigh the hazards.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex, demanding cautious thing to consider of the effects on the dad or mum drug, codeine, plus the active metabolite, morphine.